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CRM is the best predictor of local recurrence and poor survival. The 5-year follow-up of the MERCURY study showed that when the CRM was involved on a preoperative MRI, the risk of local recurrence was significantly higher and the disease-free survival reduced.[17] Taylor et al. demonstrated that when MRI demonstrated a CRM >1 mm, the rate of local recurrence was as low as 3%.[12] CRM positivity/CRM threatened implies the need for treatment intensification with NACT-RT prior to restaging for assessing resectability.

5. This examination is testing your observational, analytic, planning skills, basic radiology knowledge ( nothing more than Grainger and Allison radiology textbook), basics applied principles of basic physics radiation protection all imaging modalities.

The multicentre randomised ICU-ROX trial found that conservative O2 therapy did not significantly affect the primary end point of number of days alive and free from mechanical ventilation (ventilator-free days) compared with usual (liberal) O2 therapy [40]. Overall, 32.2% of conservative and 29.7% of usual O2 patients died in hospital. While these findings provide some reassurance to clinicians about the safety of the liberal O2 use that occurs in standard practice, they do not exclude clinically important effects of the O2 regimens tested on mortality risk. Indeed, based on the distribution of data, there is a 46% chance that conservative O2 therapy increases absolute mortality by more than 1.5% points, and a 19% chance that conservative O2 therapy decreases absolute mortality by more than 1.5% points [41, 42]. Finally, a recent RCT conducted in ICU patients fulfilling the systemic inflammatory response syndrome criteria, found no significant difference between high-normal and low-normal oxygenation targets for non-respiratory organ dysfunction over the first 14 days, or in Day-90 mortality [43]. Accordingly, the most appropriate dose of O2 to give to adult ICU patients remains uncertain. 153554b96e

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